Faculty Connections
Faculty Connections

About this site

Faculty Connections is an aggregation of UNC Charlotte faculty profiles.

Full-time faculty who want to update their profile information, see:
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      • Aaron Kampe
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    • Kailas Venkitasubramanian
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Full-Text Search

Andrew Truman

Biological Sciences
Summary | Full Profile

Office: Woodward 486C
Phone: 704-687-5228
Email: atruman1@uncc.edu
Follow us on Twitter: @trumanlab

Academic Interests
breast cancer
cancer biology
cell biology
CRISPR
mass spectrometry
molecular biology
molecular chaperones
phosphorylation
prostate cancer
protein function
protein-protein interactions
proteins
proteomics
signal transduction mechanisms
signaling pathways
yeast
Related People
ZhengChang Su
Joanna Krueger
Didier Dreau
Junya Tomida
Tingting Xiang
Adam Reitzel
Crystal N Piper
Pinku Mukherjee
Brian Cooper
Colleen Eade
Shan Yan
Jerry Troutman
Christine Richardson

The Truman Lab has moved sites! Please see:

Trumanlab.org

For undergraduate, graduate or postdoctoral research opportunities, please see here:

Research Opportunities

Hsp70 and Hsp90 are well-conserved molecular chaperones that bind and fold a a large proportion of proteins in the cell. Many cancer proteins are inherently unstable and need chaperones to maintain activity. We are interested in the basic question of the role of molecular chaperones in breast and prostate cancer.  We are focused in novel ways to manipulate Hsp70 function by either inhibiting specific “helper” co-chaperone proteins such as Hsp40 or by modulating phosphorylation on Hsp70. By “fine-tuning” Hsp70 function, we hope to identify novel ways to destabilize cancer proteins.

The Truman lab incorporates protein biochemistry, molecular biology, proteomics, systems biology, bacterial and yeast genetics and cell culture technologies.  Keywords: protein-protein interactions, protein folding, CRISPR-CAS9, breast cancer, signal transduction, phosphorylation, Hsp70, Hsp90, cell cycle, DNA damage response, yeast genetics.  

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