Phone (Lab): 704.687.8675
Office: Woodward 486A
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Regulation of liver microcirculation: Role of stress-inducible vasoactive mediators (endothelin, nitric oxide synthase, heme oxygenase) in altering vascular responsiveness in the liver following oxidative or inflammatory stress. Mechanisms of control of sinusoid perfusion by hepatic stellate cells, especially related to components of phenotypic transformation in response to injury.
Hepatic metabolic response to infection. Mechanisms of altered carbohydrate metabolism during sepsis, especially related to differentiation between inflammation-induced changes in gene expression and perfusion supply/demand ratio as mediators of decreased gluconeogenesis.
Application of imaging techniques to biological research. In vivo video microscopy for study of liver microcirculation; application of quantitative fluorescence techniques to monitoring of cellular processes in intact organs or in vivo.
Engineered liver support systems: Bioengineering Research Partnership BRP page
Research Scientist, Department of Surgery,Yale University, 1981-86
Assistant Professor, Departments of Surgery and Physiology, Johns Hopkins School of Medicine, 1986-91
Associate Professor, Departments of Surgery and Physiology, Johns Hopkins School of Medicine, 1992-96
Robert Garrett Scholar, Johns Hopkins School of Medicine, 1986-96
Director of Pediatric Surgery Research, Johns Hopkins School of Medicine, 1986-96
Professor and Chair, Department of Biological Sciences, UNC Charlotte, 1996-2005
Professor of Biological Sciences, UNC Charlotte 2005 – present
Vice President and Chief Scientific Officer, HepatoSys Inc
B.S., Physical Therapy; St. Louis University, 1975
Ph.D., Physiology; St. Louis University, 1979
Postdoctoral Fellowship, Physiology and Metabolism; Yale University, 1980-81
Courses Taught (*offered for Graduate Credit)
BIOL 3273 Animal Physiology
*BIOL 6104/8104 Integrated Systems Physiology
*BIOL 8201 PhD Seminar
*BIOL 6050 Advanced Human Physiology
*BIOL 8000 Hypothesis Testing
*BIOL 4000 / 5000 Cardiovascular Physiology
Selected Recent Publications