The consumption of fatty foods combined with a high prevalence of sedentary behavior, has led to an obesity epidemic in the United States. Obesity increases the risk of numerous adverse health outcomes, of which insulin resistance and type 2 diabetes are among the most common. There are also factors independent of obesity, such as sleep apnea and exogenous glucocorticoid exposure, which increase the risk of developing insulin resistance.
Skeletal muscle accounts for the majority of post-prandial glucose disposal. Therefore, skeletal muscle insulin resistance results in hyperglycemia. Furthermore, the insulin-signaling pathway in skeletal muscle contributes to important physiological processes that orchestrate exercise-induced adaptations. One example is the balance between protein synthesis and protein catabolism.
The Marino lab works to advance our understanding of the cellular and molecular events that cause insulin resistance, how these mechanisms are connected to exercise-mediated skeletal muscle adaptations, and the development of novel exercise intervention for those at high risk of developing type 2 diabetes.
- B.A. (2003) Exercise Science, Adelphi University, Garden City, NY
- M.A. (2004) Exercise Science, Adelphi University, Garden City, NY
- Ph.D. (2009) Applied Physiology, University of Toledo, Toledo, OH. Area of Study: The contribution of exercise-induced inflammation to skeletal muscle hypertrophy
- Postdoctoral Training (2013) University of Toledo, College of Medicine, Center for Diabetes and Endocrine Research, Toledo, OH. Area of Study: Neuro-endocrine regulation of obesity and metabolic disease
- Exercise Physiology: Principles and Application (UG)
- Principles of Strength and Conditioning (UG)
- Exercise Testing and Prescription (UG)
- Research Methods in Kinesiology (G)
1) Mechanism surrounding the pathogenesis of skeletal muscle insulin resistance
2) How insulin resistance alters the ability of skeletal muscle to properly respond to exercise
3) The development of novel exercise interventions to prevent or treat the pathogenesis of type 2 diabetes
- The office of Disability Services Outstanding Faculty Award, UNC Charlotte (2013-2014)
- The College of Health and Human Services Faculty Excellence Award in Mentoring, UNC Charlotte (2016)